Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction
نویسندگان
چکیده
منابع مشابه
Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction
MOTIVATION Sample source, procurement process and other technical variations introduce batch effects into genomics data. Algorithms to remove these artifacts enhance differences between known biological covariates, but also carry potential concern of removing intragroup biological heterogeneity and thus any personalized genomic signatures. As a result, accurate identification of novel subtypes ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2014
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btu375